Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 5/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457055 | 0.89 | AR (0.35) | MBOAT4PDE2AP2RX7ADORA2B | |
| SCHEMBL2457421 | 0.88 | ALKBH3 (0.36) | KDM4AKDM5AKDM5B | |
| SCHEMBL2455233 | 0.87 | DAO (0.38) | MBOAT4P2RX7 | |
| SCHEMBL2454918 | 0.87 | PDE1B (0.34) | KDM5AKDM5BPDE2A | |
| SCHEMBL2454685 | 0.85 | DAO (0.36) | KDM5AKDM5BPDE2AP2RX7 | |
| SCHEMBL2464506 | 0.84 | MBOAT4 (0.40) | KDM4AKDM5AKDM5BMBOAT4PLA2G7 | |
| SCHEMBL2453480 | 0.82 | MBOAT4 (0.39) | KDM4AKDM5AKDM5BMBOAT4PLA2G7 | |
| SCHEMBL2460223 | 0.82 | ENPP1 (0.43) | — | |
| SCHEMBL2456947 | 0.82 | DAO (0.33) | KDM5AKDM5B | |
| SCHEMBL2455141 | 0.81 | KDM4A (0.39) | KDM4AKDM5AKDM5BMBOAT4PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |