Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FER | P16591 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15453585 | 0.80 | CA1 (0.53) | PDK2PDK4PTGS2NTRK1 | |
| SCHEMBL15453587 | 0.80 | CA1 (0.53) | PDK2PDK4PTGS2NTRK1 | |
| SCHEMBL26327735 | 0.78 | PTGS2 (0.41) | PDK2PDK4ACVR1LRRK2ROS1 | |
| SCHEMBL17185515 | 0.72 | CA1 (0.50) | PTGS2NTRK1 | |
| SCHEMBL17185517 | 0.72 | CA1 (0.50) | PTGS2NTRK1 | |
| SCHEMBL14410532 | 0.70 | PDK2 (0.55) | PDK2PDK4ACVR1LRRK2MEN1 | |
| SCHEMBL8254175 | 0.64 | PDK2 (0.60) | PDK2PDK4ACVR1LRRK2ROS1 | |
| SCHEMBL14159310 | 0.64 | PDK2 (0.46) | PDK2PDK4MEN1KMT2A | |
| SCHEMBL2589272 | 0.61 | LRRK2 (0.57) | ACVR1LRRK2ROS1CDK5MEN1 | |
| SCHEMBL2589274 | 0.61 | LRRK2 (0.57) | ACVR1LRRK2ROS1CDK5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2880448-B1 | HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS | FOUND MEDICINE INC (US) | 2022-06-29 | — | — | EP | disclosed |