Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21766233 | 0.85 | MAPK1 (0.58) | ADORA2BMAPK1RXFP1TP53SMN1; SMN2 | |
| SCHEMBL24559262 | 0.84 | RXFP1 (0.50) | ADORA2BMAPK1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL24559409 | 0.79 | RXFP1 (0.45) | ADORA2BMAPK1RXFP1TP53SMN1; SMN2 | |
| SCHEMBL24559298 | 0.76 | ADORA2B (0.61) | ADORA2BMAPK1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL24559134 | 0.76 | RXFP1 (0.56) | ADORA2BMAPK1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL24559323 | 0.76 | RXFP1 (0.70) | ADORA2BMAPK1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL24559469 | 0.76 | THRB (0.56) | ADORA2BMAPK1RXFP1TP53SMN1; SMN2 | |
| SCHEMBL24559089 | 0.74 | ADORA2B (0.61) | ADORA2BMAPK1RXFP1LMNAALDH1A1 | |
| SCHEMBL24559396 | 0.74 | ADORA2B (0.73) | ADORA2BMAPK1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL22521931 | 0.73 | TNF (0.60) | ADORA2BMAPK1RXFP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | PARG, PARP15, PLG | ADORA2B 2231/4885MAPK1 2790/4885RXFP1 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.