Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.65 |
| ▸ | CDK7 | P50613 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | MET | P08581 | 10/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24565276 | 0.90 | ALK (0.61) | ALKMETPTK2EGFRROS1 | |
| SCHEMBL24565253 | 0.86 | ALK (0.62) | ALKINSRIGF1REGFRZAP70 | |
| SCHEMBL22460079 | 0.84 | INSR (0.56) | ALKCDK7CDK9INSRIGF1R | |
| SCHEMBL24565269 | 0.78 | ALK (0.60) | ALKMETEGFRROS1FLT3 | |
| SCHEMBL1035873 | 0.78 | ALK (0.67) | ALKMETPTK2EGFRROS1 | |
| SCHEMBL541915 | 0.78 | ALK (0.69) | ALKMETPTK2EGFRROS1 | |
| SCHEMBL1038584 | 0.77 | ALK (0.61) | ALKMETPTK2EGFRROS1 | |
| SCHEMBL24565194 | 0.76 | ALK (0.57) | ALKMETPTK2EGFRROS1 | |
| SCHEMBL24565466 | 0.76 | ALK (0.55) | ALKMETEGFRROS1FLT3 | |
| SCHEMBL24565245 | 0.76 | ALK (0.61) | ALKINSRMETEGFRROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022139386-A1 | HETEROARYL DERIVATIVE COMPOUND AND USE THEREOF | 주식회사 비투에스바이오 | 2022-06-30 | — | — | WO | disclosed |