Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23525716 | 0.85 | POLB (0.44) | POLBL3MBTL1MAPTCASP1AURKA | |
| SCHEMBL25381145 | 0.82 | ULK1 (0.38) | POLBL3MBTL1MAPTNPSR1ULK1 | |
| SCHEMBL29091371 | 0.82 | MAPT (0.38) | POLBL3MBTL1MAPTCASP1AURKA | |
| SCHEMBL30558701 | 0.82 | ULK1 (0.38) | POLBL3MBTL1MAPTNPSR1ULK1 | |
| SCHEMBL790423 | 0.78 | POLB (0.45) | POLBL3MBTL1MAPTCASP1AURKA | |
| SCHEMBL27038989 | 0.77 | POLB (0.35) | POLBL3MBTL1MAPTCASP1AURKA | |
| SCHEMBL23620104 | 0.75 | PIK3CA (0.40) | POLBL3MBTL1MAPTCASP1AURKA | |
| SCHEMBL17671136 | 0.75 | POLB (0.39) | POLBL3MBTL1MAPTCASP1AURKA | |
| SCHEMBL33961 | 0.74 | MAPT (0.44) | POLBL3MBTL1MAPTCASP1AURKA | |
| SCHEMBL4864975 | 0.74 | MAPT (0.44) | POLBL3MBTL1MAPTCASP1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |