Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18050754 | 0.82 | HSP90AB1 (0.36) | DGAT2RAB9AOPRK1KDM4EMAPT | |
| SCHEMBL31356584 | 0.80 | GSK3B (0.37) | DGAT2OPRK1KDM4EKMT2ACNR2 | |
| SCHEMBL15990933 | 0.80 | DGAT2 (0.34) | DGAT2OPRK1KDM4EKMT2ACNR2 | |
| SCHEMBL3716121 | 0.79 | OPRK1 (0.49) | OPRK1 | |
| Bromide SCHEMBL31356592 | 0.79 | GSK3B (0.36) | DGAT2KDM4ECNR2 | |
| SCHEMBL21626795 | 0.76 | DGAT2 (0.36) | DGAT2NPC1RAB9AMAPT | |
| SCHEMBL31356591 | 0.76 | OPRK1 (0.42) | DGAT2OPRK1KDM4EPTGDR2 | |
| SCHEMBL9648890 | 0.76 | OPRK1 (0.42) | DGAT2OPRK1KDM4EPTGDR2 | |
| SCHEMBL20472389 | 0.75 | OPRK1 (0.48) | NPC1RAB9AOPRK1KDM4EMAPT | |
| SCHEMBL1516793 | 0.74 | NAPRT (0.46) | OPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |