Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.51 |
| ▸ | PDE5A | O76074 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206988 | 0.88 | PDE3B (0.65) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2207452 | 0.83 | PDE5A (0.57) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2203773 | 0.77 | PDE3B (0.55) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2206103 | 0.77 | PDE3B (0.55) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2204308 | 0.76 | PDE5A (0.57) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2205488 | 0.76 | PDE3B (0.54) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2208593 | 0.76 | PDE3B (0.49) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2206307 | 0.76 | PDE5A (0.43) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2204958 | 0.76 | PDE5A (0.45) | PDE3BPDE3APDE5AMAPTKDM4E | |
| SCHEMBL2203938 | 0.76 | PDE5A (0.42) | PDE3BPDE3APDE5AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230468-A1 | FUSED HETEROCYCLIC COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230468-A1 | FUSED HETEROCYCLIC COMPOUNDS AND USES THEREOF | MCL1, FPR1, LTC4S | PDE3B 3256/4885PDE3A 3666/4885PDE5A 3946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.