Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | XPNPEP2 | O43895 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24567508 | 0.87 | GAA (0.47) | GAACYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL14355658 | 0.84 | SMN1; SMN2 (0.49) | GAACYP2C9CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL24567584 | 0.81 | LMNA (0.45) | GAACYP2C9CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL12062599 | 0.78 | POLB (0.56) | GAACYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL7398353 | 0.77 | GAA (0.45) | GAACYP2C9CYP2C19ALDH1A1KDM4E | |
| SCHEMBL13560112 | 0.75 | LMNA (0.51) | GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14355657 | 0.74 | LMNA (0.59) | CYP2C9CYP2C19ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12522321 | 0.74 | KDM4E (0.44) | GAACYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL24568671 | 0.72 | KDM4E (0.66) | GAACYP2C9CYP2C19ALDH1A1KDM4E | |
| SCHEMBL12233293 | 0.72 | EPHX2 (0.47) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140428-A2 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2022-06-30 | — | — | WO | disclosed |