Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.36 |
| ▸ | EGFR | P00533 | 6/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888720 | 1.00 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MAPTFGFR1ERBB2 | |
| SCHEMBL482648 | 0.84 | NR1H2 (0.43) | ALDH1A1SMN1; SMN2MAPTFGFR1EGFR | |
| SCHEMBL29887828 | 0.84 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MAPTGAAKMT2A | |
| SCHEMBL24569905 | 0.84 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MAPTGAAKMT2A | |
| SCHEMBL29888013 | 0.79 | ERBB2 (0.47) | ERBB2EGFR | |
| SCHEMBL24569523 | 0.79 | ERBB2 (0.47) | ERBB2EGFR | |
| SCHEMBL30137763 | 0.79 | KDR (0.36) | EGFRNR1H2BRD4TNK2HSP90AA1 | |
| SCHEMBL22076838 | 0.79 | KDR (0.36) | EGFRNR1H2BRD4TNK2HSP90AA1 | |
| SCHEMBL22076848 | 0.78 | FGFR1 (0.39) | ALDH1A1SMN1; SMN2MAPTFGFR1ERBB2 | |
| SCHEMBL1191996 | 0.77 | KMT2A (0.46) | ALDH1A1SMN1; SMN2MAPTFGFR1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |