Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24569905 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KMT2AMAPTGAAKDM4E | |
| SCHEMBL15208411 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2AMAPTGAAKDM4E | |
| SCHEMBL29888720 | 0.84 | ALDH1A1 (0.37) | ALDH1A1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL24569520 | 0.84 | ALDH1A1 (0.37) | ALDH1A1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL30478701 | 0.80 | TBXA2R (0.40) | ALDH1A1KMT2AMAPTGAAKDM4E | |
| SCHEMBL22076864 | 0.80 | TBXA2R (0.40) | ALDH1A1KMT2AMAPTGAAKDM4E | |
| SCHEMBL24570249 | 0.80 | L3MBTL1 (0.46) | ALDH1A1KMT2AMAPTGAAKDM4E | |
| SCHEMBL29888172 | 0.80 | L3MBTL1 (0.46) | ALDH1A1KMT2AMAPTGAAKDM4E | |
| SCHEMBL29025843 | 0.79 | ALDH1A1 (0.41) | ALDH1A1KMT2AMAPTGAAKDM4E | |
| SCHEMBL24569883 | 0.78 | PKM (0.47) | ALDH1A1KMT2AMAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267137-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |