SCHEMBL24569571

SCHEMBL24569571

Nc1cc(F)c(Oc2ccn3ncnc3c2)cc1F

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ERBB2 P04626 17/20 0.36
EGFR P00533 7/20 0.36
NQO2 P16083 1/20 0.35
FECH P22830 1/20 0.35
MYH14 Q7Z406 1/20 0.35
RIPK3 Q9Y572 1/20 0.35
TGFBR1 P36897 2/20 0.33
PIK3CD O00329 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24167718 0.88 MPO (0.35) ERBB2EGFRNQO2FECHMYH14
SCHEMBL22525244 0.88 ERBB2 (0.43) ERBB2EGFRNQO2FECHMYH14
SCHEMBL29888185 0.88 ERBB2 (0.43) ERBB2EGFRNQO2FECHMYH14
SCHEMBL24167904 0.85 ERBB2 (0.38) ERBB2EGFRNQO2FECHMYH14
SCHEMBL30314880 0.85 ERBB2 (0.38) ERBB2EGFRNQO2FECHMYH14
SCHEMBL25177224 0.85 NR4A1 (0.36) ERBB2EGFRNQO2FECHMYH14
SCHEMBL25174032 0.80 HSPB1 (0.34) ERBB2EGFRNQO2FECHMYH14
SCHEMBL25572680 0.80 ERBB2 (0.44) ERBB2EGFRNQO2FECHMYH14
SCHEMBL21561542 0.80 ERBB2 (0.42) ERBB2EGFRNQO2FECHMYH14
SCHEMBL30050375 0.80 ERBB2 (0.38) ERBB2EGFRNQO2FECHMYH14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078135-A1 POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 ENLIVEN INC (US) 2026-03-19 US disclosed
EP-4587124-A1 POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 Enliven Inc. (US) 2025-07-23 EP disclosed
CN-118103370-A Fused tetracyclic quinazoline derivatives as ERBB2 inhibitors 英莱汶公司 2024-05-28 CN disclosed
US-20240116921-A1 LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2024-04-11 US disclosed
WO-2024059558-A1 POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 ENLIVEN INC. (US) 2024-03-21 WO disclosed
US-20230382923-A1 FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2023-11-30 US disclosed
US-20230382923-A1 FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2023-11-30 US disclosed
US-11807649-B2 Fused tetracyclic quinazoline derivatives as inhibitors of ErbB2 ENLIVEN THERAPEUTICS, INC. (US) 2023-11-07 US disclosed
US-11807649-B2 Fused tetracyclic quinazoline derivatives as inhibitors of ErbB2 ENLIVEN THERAPEUTICS, INC. (US) 2023-11-07 US disclosed
EP-4267137-A1 LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 Enliven Inc. (US) 2023-11-01 EP disclosed
US-20230159557-A1 FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2023-05-25 US disclosed
US-20230159557-A1 FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2023-05-25 US disclosed
WO-2022140769-A1 LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN THERAPEUTICS, INC. (US) 2022-06-30 WO disclosed
WO-2022140769-A1 LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN THERAPEUTICS, INC. (US) 2022-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116921-A1 LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 ERBB2, FGFR2, ERBB3 ERBB2 1/4885EGFR 5/4885NQO2 1206/4885
US-20230159557-A1 FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ERBB2, ERBB3, BRCA1 ERBB2 1/4885EGFR 5/4885NQO2 1814/4885
US-11807649-B2 Fused tetracyclic quinazoline derivatives as inhibitors of ErbB2 ERBB2, ERBB3, BRCA1 ERBB2 1/4885EGFR 5/4885NQO2 1814/4885
US-20260078135-A1 POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 ERBB2, BRCA1, ERBB3 ERBB2 1/4885EGFR 4/4885NQO2 1591/4885
US-20230382923-A1 FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ERBB2, ERBB3, BRCA1 ERBB2 1/4885EGFR 5/4885NQO2 1814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.