Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 9/20 | 0.38 |
| ▸ | ALPL | P05186 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463735 | 0.80 | FAAH (0.43) | TNFFAAHALPLKDM4EALDH1A1 | |
| SCHEMBL2455656 | 0.79 | FAAH (0.46) | TNFFAAHALPLKDM4EALDH1A1 | |
| SCHEMBL2459586 | 0.78 | FAAH (0.47) | TNFFAAHALPLKDM4EALDH1A1 | |
| SCHEMBL2456828 | 0.77 | NPC1 (0.43) | TNFFAAHKDM4ETRPV1RAB9A | |
| SCHEMBL2461598 | 0.77 | FAAH (0.44) | TNFFAAHKDM4EALDH1A1IGF1R | |
| SCHEMBL2461026 | 0.77 | FAAH (0.44) | TNFFAAHKDM4EALDH1A1IGF1R | |
| SCHEMBL2536956 | 0.77 | FAAH (0.43) | TNFFAAHALPLKDM4EALDH1A1 | |
| SCHEMBL2454968 | 0.77 | TNF (0.42) | TNFFAAHKDM4EALDH1A1RAB9A | |
| SCHEMBL2456994 | 0.77 | FAAH (0.44) | TNFFAAHALPLKDM4EALDH1A1 | |
| SCHEMBL2463768 | 0.76 | FAAH (0.43) | TNFFAAHKDM4EALDH1A1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364316-A1 | 6, 7 -dihydro- 5h- pyrrolo [3, 4-d¨pyrimidin-4-yl]-quinolin-3 -ylamine compounds useful as FAAH modulators and uses thereof | Renovis, Inc. (US) | 2011-09-14 | — | — | EP | claimed |
| WO-2010059610-A1 | 6, 7 -DIHYDRO- 5H- PYRROLO [3, 4-D] PYRIMIDIN-4-YL] -QUINOLIN-3 -YLAMINE COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-05-27 | — | — | WO | claimed |
| EP-2364316-A1 | 6, 7 -dihydro- 5h- pyrrolo [3, 4-d¨pyrimidin-4-yl]-quinolin-3 -ylamine compounds useful as FAAH modulators and uses thereof | Renovis, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010059610-A1 | 6, 7 -DIHYDRO- 5H- PYRROLO [3, 4-D] PYRIMIDIN-4-YL] -QUINOLIN-3 -YLAMINE COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-05-27 | — | — | WO | disclosed |