Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 9/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461026 | 0.85 | FAAH (0.44) | FAAHTNFGRM4KDM4ENPC1 | |
| SCHEMBL2461598 | 0.85 | FAAH (0.44) | FAAHTNFGRM4KDM4ENPC1 | |
| SCHEMBL2455656 | 0.84 | FAAH (0.46) | FAAHTNFALPLGRM4KDM4E | |
| SCHEMBL2536956 | 0.82 | FAAH (0.43) | FAAHTNFALPLGRM4KDM4E | |
| SCHEMBL2463768 | 0.81 | FAAH (0.43) | FAAHTNFGRM4KDM4ENPC1 | |
| SCHEMBL2457036 | 0.80 | TNF (0.39) | FAAHTNFALPLKDM4ENPC1 | |
| SCHEMBL7903064 | 0.80 | FAAH (0.48) | FAAHTNFALPLGRM4KDM4E | |
| SCHEMBL2457411 | 0.79 | FAAH (0.42) | FAAHTNFGRM4KDM4ENPC1 | |
| SCHEMBL2460833 | 0.78 | FAAH (0.45) | FAAHTNFGRM4IGF1RTRPV1 | |
| SCHEMBL2490330 | 0.78 | FAAH (0.42) | FAAHTNFALPLGRM4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364316-A1 | 6, 7 -dihydro- 5h- pyrrolo [3, 4-d¨pyrimidin-4-yl]-quinolin-3 -ylamine compounds useful as FAAH modulators and uses thereof | Renovis, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010059610-A1 | 6, 7 -DIHYDRO- 5H- PYRROLO [3, 4-D] PYRIMIDIN-4-YL] -QUINOLIN-3 -YLAMINE COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-05-27 | — | — | WO | disclosed |