Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.30 |
| ▸ | AKT2 | P31751 | 2/20 | 0.30 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.30 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.30 |
| ▸ | LATS1 | O95835 | 1/20 | 0.30 |
| ▸ | PRKACB | P22694 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | GRK2 | P25098 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.30 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.30 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.30 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.30 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.30 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29735046 | 1.00 | AKT1 (0.33) | AKT1PRKACAAKT2AKT3ROCK2 | |
| SCHEMBL24573421 | 0.91 | AKT1 (0.32) | AKT1PRKACAAKT2AKT3ROCK2 | |
| SCHEMBL29734959 | 0.91 | AKT1 (0.32) | AKT1PRKACAAKT2AKT3ROCK2 | |
| SCHEMBL24573580 | 0.84 | NPBWR1 (0.35) | NPBWR1 | |
| SCHEMBL24573625 | 0.83 | AKT1 (0.34) | AKT1 | |
| SCHEMBL29735054 | 0.83 | AKT1 (0.34) | AKT1 | |
| SCHEMBL24573328 | 0.83 | TUBB4A (0.35) | ROCK2ROCK1 | |
| SCHEMBL29734219 | 0.83 | TUBB4A (0.35) | ROCK2ROCK1 | |
| SCHEMBL24573249 | 0.82 | NPBWR1 (0.34) | NPBWR1 | |
| SCHEMBL24573623 | 0.82 | AKT1 (0.33) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022137085-A1 | INDOLE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS | NOVARTIS AG (CH) | 2022-06-30 | — | — | WO | disclosed |