Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30771962 | 0.92 | IMPDH2 (0.43) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL24575364 | 0.92 | IMPDH2 (0.43) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL793650 | 0.85 | IMPDH2 (0.41) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL31468033 | 0.85 | IMPDH2 (0.41) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL30502565 | 0.76 | KDM4E (0.43) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL25254434 | 0.76 | EP300 (0.40) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL16274537 | 0.76 | IMPDH2 (0.35) | IMPDH2GAAAXLEP300KAT2B | |
| SCHEMBL31197276 | 0.76 | EP300 (0.40) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL31306384 | 0.76 | GOT1 (0.62) | IMPDH2KDM4EGAAAXLEP300 | |
| SCHEMBL26667300 | 0.76 | GOT1 (0.62) | IMPDH2KDM4EGAAAXLEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118302417-A | NLRP3 inhibitors | PTC医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-117580826-A | NLRP3 inflammation corpuscle inhibitor | 阿斯利康(瑞典)有限公司 | 2024-02-20 | — | — | CN | disclosed |
| WO-2022135567-A1 | PYRIDAZINE-CONTAINING COMPOUND AND MEDICINAL USE THEREOF | 上海拓界生物医药科技有限公司 | 2022-06-30 | — | — | WO | disclosed |