Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.59 |
| ▸ | IL1B | P01584 | 7/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24575648 | 0.96 | NLRP3 (0.59) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL24575703 | 0.93 | NLRP3 (0.68) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL31057145 | 0.93 | NLRP3 (0.68) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| Hydrochloric Acid SCHEMBL31057406 | 0.92 | NLRP3 (0.67) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL24575084 | 0.90 | IL1B (0.56) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL31057311 | 0.90 | NLRP3 (0.57) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL28934266 | 0.90 | IL1B (0.56) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL30108758 | 0.90 | IL1B (0.56) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL30214109 | 0.89 | IL1B (0.55) | NLRP3IL1BCHEK2CHEK1KCNH2 | |
| SCHEMBL29275600 | 0.89 | IL1B (0.55) | NLRP3IL1BCHEK2CHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022135567-A1 | PYRIDAZINE-CONTAINING COMPOUND AND MEDICINAL USE THEREOF | 上海拓界生物医药科技有限公司 | 2022-06-30 | — | — | WO | disclosed |