Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | SIK1 | P57059 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.31 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24578874 | 0.87 | IKBKE (0.40) | IKBKETBK1PRKAB2ABL1CSF1R | |
| SCHEMBL24577112 | 0.86 | HDAC6 (0.34) | IKBKETBK1BRD4 | |
| SCHEMBL24577155 | 0.82 | IKBKE (0.34) | IKBKETBK1 | |
| SCHEMBL24578299 | 0.81 | IKBKE (0.42) | IKBKETBK1 | |
| SCHEMBL24577132 | 0.80 | NAMPT (0.38) | — | |
| SCHEMBL24578567 | 0.79 | IKBKE (0.34) | IKBKETBK1 | |
| SCHEMBL24577993 | 0.79 | MAPT (0.31) | — | |
| SCHEMBL24577200 | 0.78 | HDAC6 (0.33) | IKBKETBK1BRD4 | |
| SCHEMBL24579014 | 0.76 | — | — | |
| SCHEMBL24577143 | 0.76 | KMT2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |