Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 6/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577185 | 0.92 | IKBKE (0.39) | IKBKETBK1KAT5CHRM1PDGFRA | |
| SCHEMBL29760142 | 0.92 | IKBKE (0.39) | IKBKETBK1KAT5CHRM1PDGFRA | |
| SCHEMBL29759818 | 0.92 | IKBKE (0.39) | IKBKETBK1KAT5CHRM1PDGFRA | |
| SCHEMBL30897453 | 0.92 | IKBKE (0.39) | IKBKETBK1KAT5CHRM1PDGFRA | |
| SCHEMBL24577258 | 0.92 | IKBKE (0.39) | IKBKETBK1KAT5CHRM1PDGFRA | |
| SCHEMBL24579086 | 0.92 | IKBKE (0.39) | IKBKETBK1KAT5CHRM1PDGFRA | |
| SCHEMBL29759874 | 0.91 | IKBKE (0.40) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577220 | 0.91 | IKBKE (0.40) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577752 | 0.90 | CHRM1 (0.40) | PIK3CACHRM1PDGFRAHRH3 | |
| SCHEMBL24577193 | 0.89 | IKBKE (0.36) | IKBKETBK1JAK2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |