Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 6/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759874 | 1.00 | IKBKE (0.40) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577629 | 0.96 | IKBKE (0.41) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL29759547 | 0.96 | IKBKE (0.41) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL29759532 | 0.93 | IKBKE (0.42) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577285 | 0.93 | IKBKE (0.42) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577195 | 0.91 | IKBKE (0.38) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL29759578 | 0.89 | CSF1R (0.40) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577482 | 0.89 | IKBKE (0.43) | IKBKETBK1JAK2JAK1TYK2 | |
| SCHEMBL24578740 | 0.89 | CSF1R (0.40) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24578953 | 0.88 | IKBKE (0.44) | IKBKETBK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |