Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577827 | 0.91 | GSK3B (0.43) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24577195 | 0.90 | IKBKE (0.38) | CHRM1PDGFRAHRH3PIK3CA | |
| SCHEMBL29759578 | 0.90 | CSF1R (0.40) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24578740 | 0.90 | CSF1R (0.40) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL29759570 | 0.88 | HRH3 (0.39) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL29760218 | 0.88 | CHRM1 (0.42) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24577852 | 0.88 | HRH3 (0.39) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24579008 | 0.88 | CHRM1 (0.42) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL24578101 | 0.87 | PDGFRA (0.41) | CHRM1PDGFRAHRH3CSF1RKIT | |
| SCHEMBL29759564 | 0.87 | PDGFRA (0.41) | CHRM1PDGFRAHRH3CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |