Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 6/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759547 | 1.00 | IKBKE (0.41) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577220 | 0.96 | IKBKE (0.40) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL29759874 | 0.96 | IKBKE (0.40) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL29759532 | 0.94 | IKBKE (0.42) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577285 | 0.94 | IKBKE (0.42) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL24577482 | 0.90 | IKBKE (0.43) | IKBKETBK1JAK2JAK1TYK2 | |
| SCHEMBL29759564 | 0.89 | PDGFRA (0.41) | IKBKETBK1JAK2HDAC6JAK1 | |
| SCHEMBL24578953 | 0.89 | IKBKE (0.44) | IKBKETBK1JAK2JAK1TYK2 | |
| SCHEMBL24578101 | 0.89 | PDGFRA (0.41) | IKBKETBK1JAK2HDAC6JAK1 | |
| SCHEMBL24577195 | 0.89 | IKBKE (0.38) | IKBKETBK1JAK2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |