Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 5/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760120 | 1.00 | PDGFRA (0.59) | PDGFRACHRM1HRH3TYK2IRAK4 | |
| SCHEMBL30809534 | 0.93 | PDGFRA (0.56) | PDGFRACHRM1HRH3TYK2IRAK4 | |
| SCHEMBL30809517 | 0.90 | PDGFRA (0.60) | PDGFRACHRM1HRH3TYK2IRAK4 | |
| SCHEMBL24578973 | 0.89 | PDGFRA (0.44) | PDGFRACHRM1HRH3TYK2IRAK4 | |
| SCHEMBL29759857 | 0.89 | PDGFRA (0.44) | PDGFRACHRM1HRH3TYK2IRAK4 | |
| SCHEMBL29759923 | 0.88 | PDGFRA (0.43) | PDGFRACHRM1HRH3TYK2IRAK4 | |
| SCHEMBL27185336 | 0.88 | PDGFRA (0.43) | PDGFRACHRM1HRH3TYK2IRAK4 | |
| SCHEMBL30809574 | 0.88 | PDGFRA (0.59) | PDGFRACHRM1HRH3IRAK4 | |
| SCHEMBL24578079 | 0.88 | PDGFRA (0.64) | PDGFRACHRM1HRH3IRAK4PDE10A | |
| SCHEMBL29760020 | 0.88 | PDGFRA (0.64) | PDGFRACHRM1HRH3IRAK4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |