Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809548 | 0.94 | PDGFRA (0.48) | PDGFRACHRM1HRH3IRAK4TYK2 | |
| SCHEMBL29760120 | 0.93 | PDGFRA (0.59) | PDGFRACHRM1HRH3IRAK4TYK2 | |
| SCHEMBL24577244 | 0.93 | PDGFRA (0.59) | PDGFRACHRM1HRH3IRAK4TYK2 | |
| SCHEMBL30809515 | 0.87 | PDGFRA (0.56) | PDGFRACHRM1HRH3IRAK4 | |
| SCHEMBL24579076 | 0.86 | CHRM1 (0.40) | PDGFRACHRM1HRH3 | |
| SCHEMBL29759802 | 0.86 | CHRM1 (0.40) | PDGFRACHRM1HRH3 | |
| SCHEMBL24578079 | 0.85 | PDGFRA (0.64) | PDGFRACHRM1HRH3IRAK4 | |
| SCHEMBL29760020 | 0.85 | PDGFRA (0.64) | PDGFRACHRM1HRH3IRAK4 | |
| SCHEMBL24578594 | 0.85 | PDGFRA (0.66) | PDGFRACHRM1HRH3IRAK4 | |
| SCHEMBL29759529 | 0.85 | PDGFRA (0.66) | PDGFRACHRM1HRH3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |