Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577394 | 0.89 | POLB (0.33) | POLBMAPK8 | |
| SCHEMBL24577325 | 0.88 | WNT1 (0.39) | POLBMAPK8WNT1GSK3BDYRK1A | |
| SCHEMBL24577373 | 0.87 | GSK3B (0.39) | POLBMAPK8WNT1GSK3BDYRK1A | |
| SCHEMBL24579106 | 0.85 | RAB9A (0.34) | POLBWNT1GSK3BDYRK1ALMNA | |
| SCHEMBL24578957 | 0.85 | RAB9A (0.34) | POLBWNT1GSK3BDYRK1ASMN1; SMN2 | |
| SCHEMBL24577267 | 0.84 | WNT1 (0.33) | POLBWNT1GSK3BDYRK1A | |
| SCHEMBL24579061 | 0.83 | POLB (0.30) | POLB | |
| SCHEMBL24577557 | 0.82 | — | — | |
| SCHEMBL24577380 | 0.81 | — | — | |
| SCHEMBL24577048 | 0.81 | WNT1 (0.31) | WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |