Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 12/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759584 | 1.00 | PDGFRA (0.40) | PDGFRACHRM1HRH3POLQCDK9 | |
| SCHEMBL30809482 | 0.99 | PDGFRA (0.40) | PDGFRACHRM1HRH3POLQCDK9 | |
| SCHEMBL30809510 | 0.98 | PDGFRA (0.40) | PDGFRACHRM1HRH3POLQCDK9 | |
| SCHEMBL30809558 | 0.90 | PDGFRA (0.41) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809553 | 0.89 | PDGFRA (0.43) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809490 | 0.89 | PDGFRA (0.44) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809496 | 0.88 | PDGFRA (0.42) | PDGFRACHRM1HRH3POLQCDK9 | |
| SCHEMBL29760118 | 0.87 | PDGFRA (0.39) | PDGFRACHRM1HRH3POLQCDK9 | |
| SCHEMBL27184971 | 0.87 | PDGFRA (0.39) | PDGFRACHRM1HRH3POLQCDK9 | |
| SCHEMBL24578004 | 0.87 | PDGFRA (0.41) | PDGFRACHRM1HRH3POLQCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2024-04-04 | — | — | US | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | PDGFRA, PDGFRB, ABL1 | PDGFRA 1/4885CHRM1 4399/4885HRH3 1593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.