Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760054 | 0.90 | PDGFRA (0.41) | PDGFRACHRM1HRH3KDM4EHSD17B10 | |
| SCHEMBL24578004 | 0.90 | PDGFRA (0.41) | PDGFRACHRM1HRH3KDM4EHSD17B10 | |
| SCHEMBL30809482 | 0.89 | PDGFRA (0.40) | PDGFRACHRM1HRH3KDM4EPOLQ | |
| SCHEMBL24577503 | 0.89 | PDGFRA (0.40) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL29759584 | 0.89 | PDGFRA (0.40) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809490 | 0.89 | PDGFRA (0.44) | PDGFRACHRM1HRH3HSD17B10ALDH1A1 | |
| SCHEMBL30809528 | 0.89 | PDGFRA (0.41) | PDGFRACHRM1HRH3POLQRAB9A | |
| SCHEMBL30809496 | 0.89 | PDGFRA (0.42) | PDGFRACHRM1HRH3POLQKIT | |
| SCHEMBL30809510 | 0.89 | PDGFRA (0.40) | PDGFRACHRM1HRH3KDM4EPOLQ | |
| SCHEMBL29760118 | 0.88 | PDGFRA (0.39) | PDGFRACHRM1HRH3POLQKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |