Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200092 | 0.80 | S1PR2 (0.50) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL13535333 | 0.76 | — | — | |
| SCHEMBL1763282 | 0.76 | — | — | |
| SCHEMBL4368152 | 0.75 | — | — | |
| SCHEMBL5362759 | 0.75 | S1PR2 (0.63) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL19441221 | 0.75 | S1PR2 (0.40) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL15534599 | 0.75 | S1PR2 (0.40) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL21984539 | 0.73 | S1PR2 (0.61) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL10974751 | 0.72 | S1PR2 (0.55) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL2015380 | 0.71 | SIGMAR1 (0.33) | S1PR2S1PR4S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |