Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30566615 | 0.99 | TGFBR1 (0.42) | TGFBR1HPGDNPC1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL29759531 | 0.99 | TGFBR1 (0.42) | TGFBR1HPGDNPC1RAB9ATP53 | |
| SCHEMBL29759559 | 0.88 | TGFBR1 (0.42) | TGFBR1HPGDNPC1RAB9ATP53 | |
| SCHEMBL24578258 | 0.84 | HTT (0.33) | TGFBR1HPGDNPC1RAB9ATP53 | |
| SCHEMBL29759692 | 0.84 | TGFBR1 (0.42) | TGFBR1HPGDNPC1RAB9ATP53 | |
| SCHEMBL24577485 | 0.84 | TGFBR1 (0.42) | TGFBR1HPGDNPC1RAB9ATP53 | |
| SCHEMBL30566539 | 0.82 | TGFBR1 (0.39) | TGFBR1KDM4E | |
| SCHEMBL24577223 | 0.78 | MAPT (0.40) | HPGDNPC1RAB9ATP53MAPT | |
| SCHEMBL30809544 | 0.77 | MAPT (0.44) | TGFBR1HPGDNPC1RAB9AMAPT | |
| SCHEMBL24577232 | 0.76 | HPGD (0.45) | TGFBR1HPGDNPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |