Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577485 | 1.00 | TGFBR1 (0.42) | TGFBR1HPGDNPC1TP53RAB9A | |
| SCHEMBL29759559 | 0.88 | TGFBR1 (0.42) | TGFBR1HPGDNPC1TP53RAB9A | |
| SCHEMBL30566541 | 0.87 | TGFBR1 (0.34) | TGFBR1L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL24579118 | 0.87 | TGFBR1 (0.34) | TGFBR1L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL24577809 | 0.84 | TGFBR1 (0.43) | TGFBR1HPGDNPC1TP53RAB9A | |
| Hydrochloric Acid SCHEMBL30566615 | 0.83 | TGFBR1 (0.42) | TGFBR1HPGDNPC1TP53RAB9A | |
| Hydrochloric Acid SCHEMBL29759531 | 0.83 | TGFBR1 (0.42) | TGFBR1HPGDNPC1TP53RAB9A | |
| SCHEMBL24577988 | 0.81 | FFAR4 (0.36) | TGFBR1HPGDNPC1RAB9AL3MBTL1 | |
| SCHEMBL30809477 | 0.79 | HPGD (0.41) | TGFBR1HPGDNPC1TP53RAB9A | |
| SCHEMBL30809480 | 0.79 | HPGD (0.41) | TGFBR1HPGDNPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |