Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 4/20 | 0.35 |
| ▸ | MLLT1 | Q03111 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759570 | 1.00 | HRH3 (0.39) | HRH3CHRM1PDGFRAWNT1GSK3B | |
| SCHEMBL29759460 | 0.92 | GSK3B (0.47) | HRH3CHRM1PDGFRAWNT1GSK3B | |
| SCHEMBL29759484 | 0.92 | GSK3B (0.47) | HRH3CHRM1PDGFRAWNT1GSK3B | |
| SCHEMBL29759956 | 0.91 | IKBKE (0.36) | HRH3CHRM1PDGFRAWNT1GSK3B | |
| SCHEMBL24577193 | 0.91 | IKBKE (0.36) | HRH3CHRM1PDGFRAWNT1GSK3B | |
| SCHEMBL24577752 | 0.88 | CHRM1 (0.40) | HRH3CHRM1PDGFRAWNT1GSK3B | |
| SCHEMBL24578740 | 0.87 | CSF1R (0.40) | HRH3CHRM1PDGFRACSF1RKIT | |
| SCHEMBL29759578 | 0.87 | CSF1R (0.40) | HRH3CHRM1PDGFRACSF1RKIT | |
| SCHEMBL24577808 | 0.86 | CHRM1 (0.39) | HRH3CHRM1PDGFRAWNT1GSK3B | |
| SCHEMBL29759804 | 0.86 | CHRM1 (0.39) | HRH3CHRM1PDGFRAWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |