Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 6/20 | 0.34 |
| ▸ | JAK1 | P23458 | 6/20 | 0.34 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759552 | 1.00 | POLQ (0.38) | POLQCCNT1CDK9JAK2JAK1 | |
| SCHEMBL27185027 | 0.94 | POLQ (0.37) | POLQCCNT1CDK9JAK2JAK1 | |
| SCHEMBL29759896 | 0.94 | POLQ (0.37) | POLQCCNT1CDK9JAK2JAK1 | |
| SCHEMBL30897452 | 0.89 | L3MBTL1 (0.42) | POLQJAK2JAK1IRAK4WNT3A | |
| SCHEMBL27185115 | 0.89 | L3MBTL1 (0.42) | POLQJAK2JAK1IRAK4WNT3A | |
| SCHEMBL27185117 | 0.89 | L3MBTL1 (0.42) | POLQJAK2JAK1IRAK4WNT3A | |
| SCHEMBL29759792 | 0.88 | IRAK4 (0.34) | POLQJAK2JAK1TYK2JAK3 | |
| SCHEMBL24577300 | 0.88 | IRAK4 (0.34) | POLQJAK2JAK1TYK2JAK3 | |
| SCHEMBL30897515 | 0.87 | WNT1 (0.34) | WNT1GSK3BDYRK1A | |
| SCHEMBL27185083 | 0.87 | WNT1 (0.34) | WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |