Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28528221 | 0.82 | HSD17B10 (0.53) | KDM4ETSHRHSD17B10ALOX15CYP2D6 | |
| SCHEMBL31270251 | 0.81 | L3MBTL1 (0.53) | KDM4EPOLBALDH1A1HSD17B10CYP2D6 | |
| SCHEMBL29929057 | 0.80 | KDM4E (0.50) | KDM4ETSHRPOLBPKMALDH1A1 | |
| SCHEMBL30498998 | 0.76 | KDM4E (0.46) | KDM4ETSHRPOLBPKMALDH1A1 | |
| SCHEMBL15733528 | 0.76 | KDM4E (0.46) | KDM4ETSHRALDH1A1CYP2D6 | |
| SCHEMBL31270162 | 0.75 | L3MBTL1 (0.46) | KDM4EPOLBALDH1A1ITGB3ITGA2B | |
| SCHEMBL1008219 | 0.74 | KDM4E (0.52) | KDM4ETSHRPOLBPKMALDH1A1 | |
| SCHEMBL1006696 | 0.74 | KDM4E (0.52) | KDM4ETSHRPOLBPKMALDH1A1 | |
| SCHEMBL31622147 | 0.74 | HDAC2 (0.40) | KDM4EALDH1A1CYP2D6HDAC2 | |
| SCHEMBL5307853 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |