Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759564 | 1.00 | PDGFRA (0.41) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24578740 | 0.96 | CSF1R (0.40) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759578 | 0.96 | CSF1R (0.40) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759824 | 0.93 | ALDH1A1 (0.43) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24577074 | 0.93 | ALDH1A1 (0.43) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24577629 | 0.89 | IKBKE (0.41) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759547 | 0.89 | IKBKE (0.41) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759755 | 0.89 | KIT (0.42) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL27185302 | 0.89 | KIT (0.44) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759814 | 0.88 | CHRM1 (0.40) | PDGFRACHRM1HRH3CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |