Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 5/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759716 | 1.00 | POLQ (0.44) | POLQPDGFRACHRM1HRH3NTRK1 | |
| SCHEMBL29759942 | 0.93 | POLQ (0.42) | POLQPDGFRACHRM1HRH3NTRK1 | |
| SCHEMBL24577500 | 0.93 | POLQ (0.42) | POLQPDGFRACHRM1HRH3NTRK1 | |
| SCHEMBL29759900 | 0.87 | POLQ (0.42) | POLQPDGFRACHRM1HRH3KDM4E | |
| SCHEMBL30809558 | 0.86 | PDGFRA (0.41) | POLQPDGFRACHRM1HRH3NTRK1 | |
| SCHEMBL30809490 | 0.86 | PDGFRA (0.44) | POLQPDGFRACHRM1HRH3ALDH1A1 | |
| SCHEMBL24577503 | 0.84 | PDGFRA (0.40) | POLQPDGFRACHRM1HRH3CDK9 | |
| SCHEMBL30809482 | 0.84 | PDGFRA (0.40) | POLQPDGFRACHRM1HRH3KDM4E | |
| SCHEMBL29759584 | 0.84 | PDGFRA (0.40) | POLQPDGFRACHRM1HRH3CDK9 | |
| SCHEMBL29760118 | 0.84 | PDGFRA (0.39) | POLQPDGFRACHRM1HRH3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |