Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2455587 | 1.00 | NPC1 (0.51) | NPC1RAB9AMCHR1MAPTTP53 | |
| SCHEMBL2459253 | 0.90 | MCHR1 (0.52) | NPC1RAB9AMCHR1MAPTTP53 | |
| SCHEMBL2451683 | 0.90 | KMT2A (0.57) | NPC1RAB9AMCHR1MAPTTP53 | |
| SCHEMBL11889812 | 0.89 | MAPT (0.49) | NPC1RAB9AMCHR1MAPTTP53 | |
| SCHEMBL29037717 | 0.85 | MEN1 (0.45) | NPC1RAB9AMCHR1MAPTLMNA | |
| SCHEMBL2453976 | 0.83 | MAPT (0.48) | NPC1RAB9AMCHR1MAPTTP53 | |
| SCHEMBL5184734 | 0.79 | NPC1 (0.64) | NPC1RAB9AMAPTTP53USP2 | |
| SCHEMBL5183604 | 0.79 | NPC1 (0.64) | NPC1RAB9AMAPTTP53USP2 | |
| SCHEMBL29252729 | 0.78 | AGTR2 (0.48) | USP2MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL6128614 | 0.77 | NAMPT (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | claimed |
| US-8012982-B2 | Modulators of HCV replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-09-06 | — | — | US | claimed |