Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451683 | 0.88 | KMT2A (0.57) | MAPTSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL2455587 | 0.83 | NPC1 (0.51) | MAPTSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL2458115 | 0.83 | NPC1 (0.51) | MAPTSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL2452227 | 0.82 | PKM (0.46) | MAPTSMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL2452210 | 0.82 | PKM (0.46) | MAPTSMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL11963285 | 0.82 | NR1H2 (0.44) | MAPTSMN1; SMN2 | |
| SCHEMBL2459253 | 0.82 | MCHR1 (0.52) | MAPTSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL5184275 | 0.81 | MAPT (0.57) | MAPTSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL11889812 | 0.81 | MAPT (0.49) | MAPTSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL29252729 | 0.77 | AGTR2 (0.48) | KMT2AMEN1ALDH1A1MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | claimed |
| US-8012982-B2 | Modulators of HCV replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-09-06 | — | — | US | claimed |