SCHEMBL2458229

SCHEMBL2458229

NS(=O)(=O)C1CC2C=CC1C2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.35
LMNA P02545 2/20 0.35
EPHX2 P34913 2/20 0.32
ALDH1A1 P00352 2/20 0.32
TDP1 Q9NUW8 2/20 0.31
GAA P10253 1/20 0.31
KMT2A Q03164 2/20 0.30
PKM P14618 2/20 0.30
MEN1 O00255 1/20 0.30
CYP3A4 P08684 1/20 0.30
ALOX15 P16050 1/20 0.30
POLB P06746 1/20 0.30
THRB P10828 1/20 0.30
CHRM1 P11229 1/20 0.30
GRIA1 P42261 1/20 0.30
GRIA2 P42262 1/20 0.30
GRIA3 P42263 1/20 0.30
RECQL P46063 1/20 0.30
GRIA4 P48058 1/20 0.30
BLM P54132 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9317589 0.86 KDM4E (0.38) KDM4ELMNAEPHX2ALDH1A1TDP1
SCHEMBL21215002 0.77 KDM4E (0.35) KDM4ELMNAEPHX2ALDH1A1TDP1
SCHEMBL16705159 0.77 KDM4E (0.35) KDM4ELMNAEPHX2ALDH1A1TDP1
SCHEMBL4545263 0.77 KDM4E (0.39) KDM4ELMNAEPHX2ALDH1A1TDP1
SCHEMBL2014878 0.77 KDM4E (0.35) KDM4ELMNAEPHX2ALDH1A1TDP1
SCHEMBL2016537 0.76 KDM4E (0.38) KDM4ELMNAEPHX2ALDH1A1TDP1
SCHEMBL2016534 0.76 KDM4E (0.34) KDM4ELMNAEPHX2ALDH1A1PKM
SCHEMBL10526491 0.72 KDM4E (0.32) KDM4ELMNA
SCHEMBL2020231 0.72 KDM4E (0.34) KDM4ELMNAALDH1A1THRB
SCHEMBL18609464 0.71 KDM4E (0.37) KDM4ELMNAEPHX2ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9395625-B2 Acrylic acid ester derivative and method for producing same, intermediate and method for producing same, high-molecular-weight compound, and photoresist composition KURARAY CO., LTD. (JP) 2016-07-19 US disclosed
US-20150037733-A1 ACRYLIC ACID ESTER DERIVATIVE AND METHOD FOR PRODUCING SAME, INTERMEDIATE AND METHOD FOR PRODUCING SAME, HIGH-MOLECULAR-WEIGHT COMPOUND, AND PHOTORESIST COMPOSITION KURARAY CO., LTD. (JP) 2015-02-05 US disclosed
EP-2821403-A1 ACRYLIC ACID ESTER DERIVATIVE AND METHOD FOR PRODUCING SAME, INTERMEDIATE AND METHOD FOR PRODUCING SAME, HIGH-MOLECULAR-WEIGHT COMPOUND, AND PHOTORESIST COMPOSITION Kuraray Co., Ltd. (JP) 2015-01-07 EP disclosed
US-8021824-B2 Polymer compound, resist composition and method of forming resist pattern TOKYO OHKA KOGYO CO., LTD. (JP) 2011-09-20 US disclosed
US-20100081080-A1 POLYMER COMPOUND, RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN TOKYO OHKA KOGYO CO., LTD. (JP) 2010-04-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150037733-A1 ACRYLIC ACID ESTER DERIVATIVE AND METHOD FOR PRODUCING SAME, INTERMEDIATE AND METHOD FOR PRODUCING SAME, HIGH-MOLECULAR-WEIGHT COMPOUND, AND PHOTORESIST COMPOSITION GFER, ASH2L, MLLT1 KDM4E 991/4885LMNA 1851/4885EPHX2 503/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.