Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 4/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15746902 | 0.89 | NR1H4 (0.55) | NR1H4TDP1POLBCYP1A2CYP2C9 | |
| SCHEMBL15745645 | 0.86 | NR1H4 (0.54) | NR1H4TDP1POLBXDHCYP1A2 | |
| SCHEMBL13714246 | 0.86 | NR1H4 (0.65) | NR1H4TDP1POLBCYP1A2CYP2C9 | |
| SCHEMBL524088 | 0.84 | POLB (0.63) | TDP1POLBXDHDHODHBRAF | |
| SCHEMBL2427949 | 0.84 | HPGD (0.51) | TDP1GCKBRAFHDAC1CYP1A2 | |
| SCHEMBL2426327 | 0.80 | KEAP1 (0.66) | TDP1POLBXDHDHODHGCK | |
| SCHEMBL145273 | 0.80 | KEAP1 (0.59) | NOTUMKDM4E | |
| SCHEMBL29780492 | 0.80 | KEAP1 (0.59) | NOTUMKDM4E | |
| SCHEMBL21274783 | 0.79 | MAOB (0.51) | POLBXDHDHODH | |
| SCHEMBL31557914 | 0.78 | MEN1 (0.60) | NR1H4TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117254-A1 | PIPERIDINE AMIDES AS MODULATORS OF THE GHRELIN RECEPTOR | PROSIDION LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |