SCHEMBL2458633

SCHEMBL2458633

O=S(=O)(c1ccccc1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.58
MAPT P10636 4/20 0.55
MAPK1 P28482 2/20 0.54
LMNA P02545 4/20 0.53
NPSR1 Q6W5P4 2/20 0.53
S1PR4 O95977 1/20 0.53
S1PR1 P21453 1/20 0.53
HTT P42858 1/20 0.53
KMT2A Q03164 1/20 0.52
ALDH1A1 P00352 5/20 0.50
POLB P06746 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
SLC16A1 P53985 1/20 0.50
CYP3A4 P08684 1/20 0.48
PGR P06401 1/20 0.47
HSD11B1 P28845 1/20 0.47
THRB P10828 1/20 0.47
TSHR P16473 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2679084 0.89 MAPT (0.54) MAPTMAPK1LMNANPSR1S1PR4
SCHEMBL30343460 0.89 MAPT (0.54) MAPTMAPK1LMNANPSR1S1PR4
SCHEMBL7168081 0.85 APEX1 (0.59) MAPTMAPK1LMNANPSR1S1PR4
SCHEMBL2381428 0.85 ALDH1A1 (0.70) MAPTMAPK1LMNAHTTKMT2A
SCHEMBL10945882 0.84 MAPT (0.60) HTR6MAPTMAPK1LMNAHTT
SCHEMBL4615892 0.82 HTR6 (0.52) HTR6MAPTMAPK1LMNANPSR1
SCHEMBL28113140 0.82 HTR6 (0.52) HTR6MAPTMAPK1LMNANPSR1
SCHEMBL4199324 0.82 HTR6 (0.52) HTR6MAPTMAPK1LMNANPSR1
SCHEMBL11112123 0.82 CA12 (0.61) HTR6MAPTMAPK1LMNANPSR1
SCHEMBL2908734 0.82 HTR6 (0.52) HTR6MAPTMAPK1LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0266662-B1 PROCESS FOR THE PREPARATION OF POLY(ARYLENSULPHIDES) WITH LOWER CRYSTALLIZATION TEMPERATURE BAYER AG (DE) 1992-06-10 EP claimed
US-4824933-A DIMENSIONAL STABILITY, CHEMICAL RESISTANT BAYER AKTIENGESELLSCHAFT (DE) 1989-04-25 US claimed
US-8853444-B2 Processes for preparing 4-chlorobenzenesulfonic acid and 4,4′-dichlorodiphenyl sulfone BASF SE (DE) 2014-10-07 US disclosed
US-20110218357-A1 PROCESSES FOR PREPARING 4-CHLOROBENZENESULFONIC ACID AND 4,4'-DICHLORODIPHENYL SULFONE BASF SE (DE) 2011-09-08 US disclosed
US-20030065131-A1 PROCESS FOR THE PREPARATION OF POLYARYLENE SULFIDE DAINIPPON INK AND CHEMICALS, INCORPORATED (JP) 2003-04-03 US disclosed
US-4873372-A Isolation of 4,4'-dichlorodiphenyl sulfone BASF AKTIENGESELLSCHAFT (DE) 1989-10-10 US disclosed
US-4824933-A DIMENSIONAL STABILITY, CHEMICAL RESISTANT BAYER AKTIENGESELLSCHAFT (DE) 1989-04-25 US disclosed