⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25356001 | 1.00 | — | — | |
| SCHEMBL2944202 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL20166384 | 0.97 | LMNA (0.36) | — | |
| Hydrochloric Acid SCHEMBL20167235 | 0.97 | LMNA (0.36) | — | |
| Hydrochloric Acid SCHEMBL18172348 | 0.97 | LMNA (0.36) | — | |
| Hydrochloric Acid SCHEMBL20166382 | 0.95 | LMNA (0.35) | — | |
| Hydrochloric Acid SCHEMBL20167404 | 0.95 | LMNA (0.35) | — | |
| Hydrochloric Acid SCHEMBL20167233 | 0.95 | LMNA (0.35) | — | |
| SCHEMBL23653825 | 0.85 | LMNA (0.32) | — | |
| SCHEMBL7994599 | 0.83 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783187-A | Preparation of tetrahydroindazole derivatives as novel diacylglycerol O-acyltransferase 2 inhibitors | 默沙东有限责任公司 | 2023-09-19 | — | — | CN | disclosed |
| EP-4153584-A1 | NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-03-29 | — | — | EP | disclosed |
| WO-2022140169-A1 | PREPARATION OF TETRAHYDROINDAZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-06-30 | — | — | WO | disclosed |