Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 7/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464957 | 0.88 | NR3C1 (0.33) | NR3C1PDE2A | |
| SCHEMBL2465875 | 0.82 | NR3C1 (0.33) | NR3C1PDE2A | |
| SCHEMBL2461383 | 0.81 | PDE2A (0.39) | NR3C1PDE2ATSHR | |
| SCHEMBL2457418 | 0.78 | CCR2 (0.42) | NR3C1PDE2A | |
| SCHEMBL2456944 | 0.78 | PDE2A (0.41) | NR3C1PDE2A | |
| SCHEMBL12324676 | 0.78 | PDE2A (0.39) | NR3C1PDE2A | |
| SCHEMBL2460219 | 0.78 | CCR2 (0.46) | NR3C1PDE2A | |
| SCHEMBL2455160 | 0.78 | CCR2 (0.43) | NR3C1PDE2ATSHR | |
| SCHEMBL2459400 | 0.77 | NR3C1 (0.39) | NR3C1PDE2ATSHR | |
| SCHEMBL2459353 | 0.76 | GRIN1 (0.32) | CYP11B1CYP11B2TSHRGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |