Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 1/20 | 0.52 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 5/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459363 | 1.00 | IRAK1 (0.52) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL2463486 | 0.94 | IDO1 (0.54) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL2460443 | 0.94 | IDO1 (0.54) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL2460448 | 0.94 | IDO1 (0.54) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL16336888 | 0.90 | IRAK1 (0.53) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL16337471 | 0.90 | IRAK1 (0.53) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL15055944 | 0.90 | IRAK1 (0.53) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL2126475 | 0.90 | IRAK1 (0.53) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL2126478 | 0.90 | IRAK1 (0.53) | IRAK1ACKR3IDO1TDO2MERTK | |
| SCHEMBL2464315 | 0.89 | IRAK1 (0.52) | IRAK1ACKR3IDO1TDO2MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| WO-2009124965-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | PRKCZ, PRKCQ, PRKCD | IRAK1 1527/4885ACKR3 977/4885IDO1 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.