Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.54 |
| ▸ | TDO2 | P48775 | 1/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460443 | 1.00 | IDO1 (0.54) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL2460448 | 1.00 | IDO1 (0.54) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL2459367 | 0.94 | IRAK1 (0.52) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL2459363 | 0.94 | IRAK1 (0.52) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL17764590 | 0.94 | BCDIN3D (0.51) | IDO1TDO2CCNT1CDK9BCDIN3D | |
| SCHEMBL16337782 | 0.90 | IDO1 (0.51) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL16337321 | 0.90 | IDO1 (0.51) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL15056440 | 0.90 | IDO1 (0.51) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL15056511 | 0.89 | IDO1 (0.50) | IDO1TDO2CCNT1CDK9IRAK1 | |
| SCHEMBL15056512 | 0.89 | IDO1 (0.50) | IDO1TDO2CCNT1CDK9IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| WO-2009124965-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | PRKCZ, PRKCQ, PRKCD | IDO1 1771/4885TDO2 1909/4885CCNT1 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.