Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.49 |
| ▸ | BMX | P51813 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463010 | 0.84 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL9985033 | 0.81 | BTK (0.52) | BTKFGRSRCTECBMX | |
| SCHEMBL2460140 | 0.78 | BTK (0.43) | BTKFGRSRCTECBMX | |
| SCHEMBL19971530 | 0.78 | BTK (0.40) | BTKFGRSRCTECBMX | |
| SCHEMBL2459433 | 0.77 | BTK (0.54) | BTKFGRSRCTECBMX | |
| SCHEMBL19981552 | 0.72 | BTK (0.59) | BTKFGRSRCTECBMX | |
| SCHEMBL2461521 | 0.72 | BTK (0.45) | BTKFGRSRCTECBMX | |
| SCHEMBL2462218 | 0.71 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2491887 | 0.69 | BTK (0.69) | BTKFGRSRCTECBMX | |
| SCHEMBL9984618 | 0.69 | BTK (0.75) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-A1 | Pyridazinones and their use as btk inhibitors | CGI Pharmaceuticals, Inc. (US) | 2011-09-21 | — | — | EP | disclosed |
| WO-2010056875-A1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |