Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 20/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130306 | 0.90 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL24595469 | 0.80 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL27188770 | 0.78 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL21130083 | 0.78 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL22494872 | 0.74 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL22495027 | 0.74 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL28477494 | 0.74 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL22509871 | 0.72 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL23429781 | 0.71 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL21684379 | 0.70 | PRMT5 (0.38) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |