Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | NEK4 | P51957 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464049 | 0.81 | KDR (0.51) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL28994195 | 0.80 | GRM5 (0.53) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL2459015 | 0.80 | MAPT (0.65) | TSHRKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL17892561 | 0.80 | NPSR1 (0.49) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL30643204 | 0.79 | GRM5 (0.62) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL17392022 | 0.78 | DEGS1 (0.62) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL28994232 | 0.78 | BTK (0.62) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL12859107 | 0.78 | ABL1 (0.56) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL1972210 | 0.78 | ALOX15 (0.52) | ALOX15TSHRCASP1NPSR1HSD17B10 | |
| SCHEMBL2462314 | 0.77 | KDR (0.48) | ALOX15TSHRCASP1NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044041-B2 | e.g. 4-Chloro-1-hydroxy-phthalazine-6-carboxylic acid [4-chloro-3'-(2-dimethylamino-ethoxy)-biphenyl-3-yl]-amide; multifunctioning protein kinase inhibitors; anticarcinogenic, antiinflammatory, antidiabetic agent, neurodegenerative diseases | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-10-25 | — | — | US | disclosed |
| US-20110237571-A1 | PHTHALAZINE DERIVATIVES | ARALDI GIAN-LUCA | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237571-A1 | PHTHALAZINE DERIVATIVES | CDK5, HIPK2, PACSIN2 | ALOX15 3492/4885TSHR 4334/4885CASP1 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.