Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | USP2 | O75604 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 5/20 | 0.38 |
| ▸ | CASP7 | P55210 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24596206 | 0.81 | MAT2A (0.46) | KDM4EALDH1A1USP2HSD17B10CYP3A4 | |
| SCHEMBL29789993 | 0.76 | MAT2A (0.47) | CYP3A4CYP2C9CYP2C19CYP2D6LMNA | |
| SCHEMBL24596310 | 0.76 | MAT2A (0.47) | CYP3A4CYP2C9CYP2C19CYP2D6LMNA | |
| SCHEMBL24596301 | 0.71 | MAT2A (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL7340105 | 0.70 | PDE4A (0.74) | KDM4EALDH1A1LMNAADORA3PDE4A | |
| SCHEMBL29789974 | 0.69 | MAT2A (0.58) | CYP3A4CYP2C9CYP2C19MAT2A | |
| SCHEMBL24596149 | 0.69 | MAT2A (0.58) | CYP3A4CYP2C9CYP2C19MAT2A | |
| SCHEMBL29789942 | 0.68 | MAT2A (0.51) | CYP3A4CYP2C9CYP2C19PDE4APDE4B | |
| SCHEMBL26631709 | 0.68 | MAT2A (0.51) | CYP3A4CYP2C9CYP2C19PDE4APDE4B | |
| SCHEMBL22724482 | 0.68 | USP2 (0.49) | ALDH1A1USP2HSD17B10CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4273146-A1 | TRICYCLIC COMPOUND AND USE THEREOF | Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022143864-A1 | TRICYCLIC COMPOUND AND USE THEREOF | 江苏先声药业有限公司 | 2022-07-07 | — | — | WO | disclosed |