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SCHEMBL24596200

SCHEMBL24596200

Cc1nc2c(=O)n(-c3ccccc3Cl)c3nc(C(F)(F)F)ccc3c2[nH]1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MAT2A P31153 16/20 0.57
▸ HCAR1 Q9BXC0 1/20 0.38
▸ PARP1 P09874 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ CYP2D6 P10635 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ PDE9A O76083 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29789960 0.89 MAT2A (0.57) MAT2APDE9A
SCHEMBL24596293 0.89 MAT2A (0.57) MAT2APDE9A
SCHEMBL24596273 0.88 MAT2A (0.58) MAT2AALDH1A1PDE9A
SCHEMBL24596189 0.87 MAT2A (0.62) MAT2A
SCHEMBL24596191 0.84 MAT2A (0.53) MAT2AHCAR1
SCHEMBL24596241 0.84 MAT2A (0.60) MAT2AHCAR1ALDH1A1PDE9A
SCHEMBL24596307 0.82 MAT2A (0.58) MAT2A
SCHEMBL24596304 0.80 MAT2A (0.56) MAT2AHCAR1ALDH1A1PDE9A
SCHEMBL24596312 0.80 MAT2A (0.58) MAT2AALDH1A1
SCHEMBL24596198 0.79 MAT2A (0.57) MAT2AALDH1A1CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4273146-A1 TRICYCLIC COMPOUND AND USE THEREOF Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) 2023-11-08 — — EP disclosed
WO-2022143864-A1 TRICYCLIC COMPOUND AND USE THEREOF 江苏先声药业有限公司 2022-07-07 — — WO disclosed