Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 14/20 | 0.56 |
| ▸ | PDE9A | O76083 | 2/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24596241 | 0.83 | MAT2A (0.60) | MAT2APDE9APDE1CKDM4EALDH1A1 | |
| SCHEMBL24596273 | 0.81 | MAT2A (0.58) | MAT2APDE9APDE1CKDM4EALDH1A1 | |
| SCHEMBL24596200 | 0.80 | MAT2A (0.57) | MAT2APDE9AALDH1A1HCAR1 | |
| SCHEMBL29789946 | 0.79 | MAT2A (0.58) | MAT2AKDM4EALDH1A1S1PR4GLA | |
| SCHEMBL24596171 | 0.79 | MAT2A (0.58) | MAT2AKDM4EALDH1A1S1PR4GLA | |
| SCHEMBL24596312 | 0.79 | MAT2A (0.58) | MAT2AKDM4EALDH1A1 | |
| SCHEMBL24596307 | 0.79 | MAT2A (0.58) | MAT2A | |
| SCHEMBL24596189 | 0.78 | MAT2A (0.62) | MAT2A | |
| SCHEMBL24596293 | 0.78 | MAT2A (0.57) | MAT2APDE9A | |
| SCHEMBL29789960 | 0.78 | MAT2A (0.57) | MAT2APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4273146-A1 | TRICYCLIC COMPOUND AND USE THEREOF | Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022143864-A1 | TRICYCLIC COMPOUND AND USE THEREOF | 江苏先声药业有限公司 | 2022-07-07 | — | — | WO | disclosed |