Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363270 | 0.76 | PDK2 (0.47) | OPRL1PDK2CYP1A2HTR1ASLC6A2 | |
| SCHEMBL23853811 | 0.74 | HTR1A (0.40) | OPRL1GRM4HTR1ASLC6A2SLC6A4 | |
| SCHEMBL2614922 | 0.74 | OPRL1 (0.59) | OPRL1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL31703523 | 0.74 | OPRL1 (0.38) | OPRL1PDK2CYP1A2 | |
| SCHEMBL23137409 | 0.74 | OPRL1 (0.38) | OPRL1PDK2GRM4SLC6A2 | |
| SCHEMBL2645775 | 0.74 | COMT (0.42) | OPRL1PDK2 | |
| SCHEMBL29879632 | 0.74 | OPRL1 (0.48) | OPRL1PDK2GRM4 | |
| SCHEMBL23362965 | 0.74 | OPRL1 (0.38) | OPRL1PDK2CYP1A2 | |
| SCHEMBL8233305 | 0.74 | OPRL1 (0.48) | OPRL1PDK2GRM4 | |
| SCHEMBL30137135 | 0.74 | OPRL1 (0.59) | OPRL1HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022143864-A1 | TRICYCLIC COMPOUND AND USE THEREOF | 江苏先声药业有限公司 | 2022-07-07 | — | — | WO | disclosed |